Title: Chemical Biology of DNA Damage and Repair
Speaker: Prof. Deyu Li, PhD
Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island
Abstract:The human genome is constantly challenged by endogenous and exogenous sources, such as reactive oxygen species (ROS), ultraviolet (UV) light, and various carcinogens. Each of these DNA damaging agents forms adducts and generates unique mutational patterns, which hold promise for disease diagnosis and prevention. Our lab focuses on the mutagenesis of DNA lesions, including their formation, replication bypass and repair. By using a combination of tools from chemistry, molecular biology, and genetics, we hope to construct mutational spectra and repair/bypass maps of DNA damaging agents. These works may provide strategies to prevent diseases caused by toxins or to solve the problems of drug resistance.
