Title: Fun with Unusual Functional Groups
Speaker: Prof. Shyam Sathyamoorthi, PhD
Department of Medicinal Chemistry, University of Kansas
Abstract: Compared to ubiquitous functional groups such as alcohols, carboxylic acids, amines, and amides, which serve as central “actors” in most organic reactions, sulfamates, phosphoramidates, and di-tert-butyl silanols have historically been viewed as “extras”. Largely considered functional group curiosities rather than launchpoints of vital reactivity, the chemistry of these moieties is underdeveloped. Our research program has uncovered new facets of reactivity of each of these functional groups, and we are optimistic that the chemistry of these fascinating molecules can be developed into truly general transformations, useful for chemists across multiple disciplines. In the ensuing sections, I will describe our efforts to develop new reactions with these “unusual” functional groups, namely sulfamates, phosphoramidates, and di-tert-butyl silanols.
