Title: The Differences Between the Natural Product Streptothricin and a 4(1H)-Quinolone Small Molecule that Make One a Better Antibacterial and the Other a Better Antimalarial
Speaker: Prof. Roman Manetsch
Department of Chemistry and Chemical Biology, and Department of Pharmaceutical Sciences, Northeastern University, Boston, MA, 02115
Abstract: The recent rise in drug resistance against current anti-microbial drugs necessitates the identification and development of alternative agents. The Manetsch laboratory focuses on the development and implementation of LC-MS-guided synthetic and medicinal chemistry approaches for the identification and optimization of antimicrobial agents. This seminar focuses on: (1) a diversity-oriented total synthesis of streptothricin F, an aminoglycoside-like natural product with broad-spectrum antimicrobial activity, and streptothricin’s antibacterial activity profile; and (2) the discovery and development of an orally bioavailable 4(1H)-quinolone as a novel chemotype targeting the liver, blood, and transmitting stages of Plasmodium falciparum.
