Title: Nanopore biosensing: from proteomics, genomics, and drug discovery
By: Prof. Min Chen, University of Massachusetts Amherst
Abstract: Nanopore sensing is based on detecting minute alterations in ionic flow through a nano-sized hole in the membrane. The introduction of nanopore DNA sequencing, due to its ability to achieve exceptionally long reads and directly identify modified nucleotides, has forever altered the landscape of genomic research, offering unprecedented insights into previously inaccessible information in our genome. However, the impact of nanopore technology extends beyond DNA sequencing. Ongoing efforts in academia and industry promise to bring similar advances to epigenomics, (epi)transcriptomics, proteomics, metabolomics, and drug development. In this talk, I will describe our efforts to develop nanopore platforms for improved RNA sequencing, for protein identification and allosteric drug screening.
